abstract：PURPOSE:To investigate the expression of sex steroid receptors in gastric cancer and to correlate their tumor expression profile with the clinicopathological parameters and overall survival of the patients. METHODS:Immunohistochemical methodology was employed in formalin-fixed paraffin-embedded sections from 86 patien...

journal_title：Journal of cancer research and clinical oncology

authors： Kominea A,Konstantinopoulos PA,Kapranos N,Vandoros G,Gkermpesi M,Andricopoulos P,Artelaris S,Savva S,Varakis I,Sotiropoulou-Bonikou G,Papavassiliou AG

更新日期：2004-05-01 00:00:00

abstract：:Metastasis remains one of the major challenges before hepatocellular carcinoma (HCC) is finally conquered. This paper summarized a decade's studies on HCC metastasis at the Liver Cancer Institute of Fudan University. We have established a stepwise metastatic human HCC model system, which included a metastatic HCC mode...

journal_title：Journal of cancer research and clinical oncology

authors： Tang ZY,Ye SL,Liu YK,Qin LX,Sun HC,Ye QH,Wang L,Zhou J,Qiu SJ,Li Y,Ji XN,Liu H,Xia JL,Wu ZQ,Fan J,Ma ZC,Zhou XD,Lin ZY,Liu KD

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Promising new therapies for neoplasia include tyrosine kinase receptor antagonists. Tyrosine kinase oncogenes present an appealing anti-tumor drug target since they play an integral role in a variety of cellular responses including cell proliferation and differentiation. We previously demonstrated a high rate o...

journal_title：Journal of cancer research and clinical oncology

authors： Henley JD,Cummings OW,Loehrer PJ Sr

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Within hypoxic tumor regions anaerobic dissimilation of glucose is the sole source of energy generation. It yields only 5% of the ATP that is normally gained by means of oxidative glucose catabolism. The increased need for glucose may aggravate cancer cachexia. We investigated the impact of recombinant human...

journal_title：Journal of cancer research and clinical oncology

authors： van Halteren HK,Bongaerts GP,Verhagen CA,Kamm YJ,Willems JL,Grutters GJ,Koopman JP,Wagener DJ

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed So...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukamoto T,Inada K,Tanaka H,Mizoshita T,Mihara M,Ushijima T,Yamamura Y,Nakamura S,Tatematsu M

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of a biweekly CHOP regimen consisting of cyclophosphamide (CPA), doxorubicin (DOX), vincristine (VCR), and prednisolone (PSL) and those of a biweekly THP-COP regimen containing pirarubicin (THP), an anthracyclin with less cardiotoxicity than DOX. METHODS:A prospective, random...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Yamada T,Sawada M,Kasahara S,Kanemura N,Kojima Y,Fukuno K,Hara T,Saio M,Takahashi T,Oyama M,Ozawa K,Takami T,Moriwaki H

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To determine the cytotoxicity of, and radioenhancement by, gemcitabine on a glioma cell line grown as a monolayer and as spheroid cultures. MATERIAL AND METHODS:We used a human glioma cell line, Gli-6, which originated from a biopsy specimen of a patient with a glioblastoma multiforme. Spheroids...

journal_title：Journal of cancer research and clinical oncology

authors： Genç M,Castro Kreder N,Barten-van Rijbroek A,Stalpers LJ,Haveman J

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：:Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are markers of collagen absorption and LP is specific for collagen type I in bone. In the present study we evaluated the concentration of HP and LP in urine of patients with osteosarcoma ( n=20; age range 16-49 years) and chondrosarcoma ( n=15; age range 18-70 y...

journal_title：Journal of cancer research and clinical oncology

authors： Açil Y,Springer I,Behrens P,Ullrich KP,Hedderich J,Bruns J

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Human papillomavirus (HPV) type 16 and 18 are the most prevalent genotypes in cervical cancers. The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded dendritic cells (DC) were evaluated as cellular tumor vaccine. METHODS:Autologous monocyte-derive...

journal_title：Journal of cancer research and clinical oncology

authors： Nonn M,Schinz M,Zumbach K,Pawlita M,Schneider A,Dürst M,Kaufmann AM

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Serrated adenomas (SAs), which include a wide spectrum of lesions, can be broadly divided into two subtypes: type I, closely mimicking hyperplastic polyps (HPs), and type II, unequivocal adenomatous tumor. Our preliminary findings showed clinicopathologic differences between them. The present study was conducte...

journal_title：Journal of cancer research and clinical oncology

authors： Mitomi H,Sada M,Kobayashi K,Igarashi M,Mori A,Kanazawa H,Nishiyama Y,Ihara A,Otani Y

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:The epithelial cell adhesion molecule (Ep-CAM) is a clinically validated target for antibody-based therapy of cancer. The aim of this work was to evaluate the specific cytotoxic activity of a novel fully human Ep-CAM-specific IgG1 antibody, called MT201, against primary ovarian tumor cells and an ovarian tumor ...

journal_title：Journal of cancer research and clinical oncology

authors： Xiang W,Wimberger P,Dreier T,Diebold J,Mayr D,Baeuerle PA,Kimmig R

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:G-protein-coupled receptors are known to mediate cell growth via divergent signaling pathways. It has been reported that colon cancer cells express muscarinic acetylcholine receptor (mAChR) although their functional role is largely unknown. The aim of this study is to elucidate possible mechanisms responsible f...

journal_title：Journal of cancer research and clinical oncology

authors： Ukegawa JI,Takeuchi Y,Kusayanagi S,Mitamura K

更新日期：2003-05-01 00:00:00

abstract：:Cancer development depends on the aberrant activation of signal transduction pathways that control cell growth and survival and play important roles in normal embryonic development. This review will focus on one of the most powerful pathways, the canonical Wnt signal transduction cascade, which has been originally des...

journal_title：Journal of cancer research and clinical oncology

authors： Lustig B,Behrens J

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To study the effects of surgery and timing of radiotherapy on patient survival in grade 2 gliomas. METHODS:One hundred and eighty-nine patients with diffuse astrocytomas, oligoastrocytomas, and oligodendrogliomas, World Health Organization grade 2, treated between 1982 and 2000 were identified. The impact of t...

journal_title：Journal of cancer research and clinical oncology

authors： Ribom D,Smits A,Hartman M,Persson L,Blomquist E

更新日期：2003-03-01 00:00:00

abstract：:The occurrence of malignancies during pregnancy has increased over the last decades. They complicate approximately 1 per 1000 pregnancies. The most common malignancies associated with pregnancy include malignant melanoma, malignant lymphomas and leukemia, and cancer of the cervix, breast, ovary, colon and thyroid. Sin...

journal_title：Journal of cancer research and clinical oncology

authors： Oduncu FS,Kimmig R,Hepp H,Emmerich B

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:As previously described, SPC/myc transgenic mice developed bronchioloalveolar adenocarcinomas derived from alveolar type II (AT II) cells within 10-14 months, whereas SPC/IgEGF transgenic mice developed hyperplasias. Our purpose was to determine the potential interplay of environmental and genetic factors in lu...

journal_title：Journal of cancer research and clinical oncology

authors： Ehrhardt A,Bartels T,Klocke R,Paul D,Halter R

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To establish a hepatocellular carcinoma (HCC) cell line from lung metastatic lesions of human HCC in nude mice so as to provide a suitable model for the study of lung-metastasis-related molecular mechanisms. METHODS:HCC clone cells MHCC97-H were inoculated into BALB/c nude mice, and the pulmonary metastatic le...

journal_title：Journal of cancer research and clinical oncology

authors： Li Y,Tang Y,Ye L,Liu B,Liu K,Chen J,Xue Q

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:In the present study an antigen-mimetic peptide of the anti-JL1 leukemia-specific monoclonal antibody (mAb) was identified and characterized. METHODS:From combinatorial peptide phage display libraries displaying the random linear heptapeptides and dodecapeptides, we selected clones with affinity to anti-JL1 mA...

journal_title：Journal of cancer research and clinical oncology

authors： Chung J,Park S,Kim D,Rhim J,Kim I,Choi I,Yi K,Ryu S,Suh P,Chung D,Bae Y,Shin Y,Park S

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:Since continuous relapse rates are characteristic for advanced low-grade non-Hodgkin's lymphomas (NHL), their treatment remains a problem. Previous phase II studies showed that bendamustine induced high remission rates in pre-treated low-grade NHL. To further examine its efficacy and side effects, bendamustine ...

journal_title：Journal of cancer research and clinical oncology

authors： Bremer K

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene. METHODS:We studied mRNA expression of all three transmembrane CAs - CA IX, XII, and XIV - in 17 RCC cell lines, tr...

journal_title：Journal of cancer research and clinical oncology

authors： Ashida S,Nishimori I,Tanimura M,Onishi S,Shuin T

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:The primary cause of local recurrence and therapeutic failure in the treatment of malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it is known that malignant gliomas infiltrate diffusely into regions of normal brain, it is frequently very difficult to unequivocally ident...

journal_title：Journal of cancer research and clinical oncology

authors： Jung S,Kim HW,Lee JH,Kang SS,Rhu HH,Jeong YI,Yang SY,Chung HY,Bae CS,Choi C,Shin BA,Kim KK,Ahn KY

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To investigate antitumour efficacy of the combination of the antiangiogenic agent TNP-470 combined with chemoimmunotherapy in different tumour models in mice MATERIALS:B6D2F1 mice and BALB/c mice were inoculated in the footpad of the right hind limb with B16F10 melanoma cells or colon adenocarcinoma cells C-26...

journal_title：Journal of cancer research and clinical oncology

authors： Dabrowska-Iwanicka A,Olszewska D,Jalili A,Makowski M,Grzela T,Marczak M,Hoser G,Giermasz A,Golab J,Jakóbisiak M

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:We studied the antitumor activity of 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one (Phx), which was synthesized by the reactions of 2-amino-5-methylphenol with bovine hemoglobin, on human B cell lymphoblastoid cell lines, P3HR-1 and Raji derived from African Burkitt's lymphoma, and the human T...

journal_title：Journal of cancer research and clinical oncology

authors： Koshibu-Koizumi J,Akazawa M,Iwamoto T,Takasaki M,Mizuno F,Kobayashi R,Abe A,Tomoda A,Hamatake M,Ishida R

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:In stomach adenocarcinoma, the role of the hormonal receptor, estrogen receptor (ER), has been controversial. Recently, a new estrogen receptor, called estrogen receptor beta (ER beta), was found to be expressed in various tissues including normal gastrointestinal tract. In this paper, the expression of ER beta...

journal_title：Journal of cancer research and clinical oncology

authors： Matsuyama S,Ohkura Y,Eguchi H,Kobayashi Y,Akagi K,Uchida K,Nakachi K,Gustafsson JA,Hayashi S

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases MMP-2 and MMP-9 are implicated in invasion and metastasis of malignant tumors. We investigated the expression and activation of MMP-2 and MMP-9 in lung cancer compared with normal lung parenchyma, and looked for a potential marker of malignancy. METHODS:Thirty-six pulmonary carcinomas...

journal_title：Journal of cancer research and clinical oncology

authors： Hrabec E,Strek M,Nowak D,Greger J,Suwalski M,Hrabec Z

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:About 40% of non-small cell lung cancer (NSCLC) patients are candidates for systemic chemotherapy, despite the fact that at diagnosis most NSCLC are usually chemoresistant both in vivo and ex vivo. It is important to develop sufficient methods of prediction of the response to chemotherapy and to find molecular ...

journal_title：Journal of cancer research and clinical oncology

authors： Vogt U,Zaczek A,Klinke F,Granetzny A,Bielawski K,Falkiewicz B

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:The activity of dihydropyrimidine dehydrogenase (DPD) - the rate-limiting enzyme in fluorouracil (5-FU) catabolism - has been reported to vary according to the time of day. On the basis of this data, so-called chronomodulated chemotherapy regimens with variable-rate infusions of 5-FU have been investigated in t...

journal_title：Journal of cancer research and clinical oncology

authors： Raida M,Kliche KO,Schwabe W,Häusler P,Clement JH,Behnke D,Höffken K

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Many biochemical processes are closely related to ion exchange, adsorption, and catalysis. Zeolites reversibly bind small molecules such as oxygen or nitric oxide; they possess size and shape selectivity, the possibility of metalloenzyme mimicry, and immunomodulatory activity. These properties make them interes...

journal_title：Journal of cancer research and clinical oncology

authors： Pavelic K,Katic M,Sverko V,Marotti T,Bosnjak B,Balog T,Stojkovic R,Radacic M,Colic M,Poljak-Blazi M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Small cell lung carcinoma (SCLC) expresses phenotypic features of pulmonary neuroendocrine cells and demonstrates a strong etiologic association with smoking. SCLC cell lines express a Raf-1-dependent mitogenic signal transduction pathway, which is thought to transduce the mitogenic signals initiated by neuro...

journal_title：Journal of cancer research and clinical oncology

authors： Jull BA,Plummer HK 3rd,Schuller HM

更新日期：2001-12-01 00:00:00

abstract：:Passively administered and actively induced antibodies have been associated with the eradication of circulating tumor cells and micrometastases in mice and humans. We have identified a series of cell surface carbohydrate and peptide antigens on melanomas, sarcomas, and cancer of the breast, prostate. ovary, and lung t...

journal_title：Journal of cancer research and clinical oncology

authors： Musselli C,Livingston PO,Ragupathi G

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases (MMPs) are a family of structurally related zinc-dependent endopeptidases that are able to degrade extracellular matrix components. MMPs play a role in tumor invasion and tumor metastasis. MMP-2 (also known as gelatinase A) is expressed in human melanoma cells. METHODS:In this study, ...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Hipler UC,Knöll B,Graefe T,Kaatz M,Kirsch K

更新日期：2001-10-01 00:00:00

abstract：AIM:To study the role of beta-catenin gene mutation and expression in hepatocellular carcinogenesis. METHOD:Thirty-four hepatocellular carcinoma (HCC) specimens and adjacent para-cancerous tissues, and four normal liver tissues were analyzed. Subcellular distribution of beta-catenin was examined by immunohistochemistr...

journal_title：Journal of cancer research and clinical oncology

authors： Cui J,Zhou X,Liu Y,Tang Z

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:beta-1,4-Galactosyltransferase (beta-1,4-GalT) I, II, and V are the enzymes responsible for the biosynthesis of N-acetyllactosamine on N-glycans by transferring UDP-galactose to the terminal N-acetylglucosamine (N-GlcNAc) residues with the formation of a beta-1,4-linkage. Neoplasms undergo various changes in th...

journal_title：Journal of cancer research and clinical oncology

authors： Xu S,Zhu X,Zhang S,Yin S,Zhou L,Chen C,Gu J

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

journal_title：Journal of cancer research and clinical oncology

authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:The p16/cyclin D1/pRb pathway plays a critical role in tumourigenesis. We recently reported alterations in expression of tumour suppressor gene products, p16 and pRb in esophageal cancer. Knowledge of alterations in cyclin D1, a vital component of this pathway in esophageal carcinomas from the Indian subcontine...

journal_title：Journal of cancer research and clinical oncology

authors： Mathew R,Arora S,Khanna R,Shukla NK,Mathur M,Ralhan R

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Tumor suppressor gene therapy and cytokine gene therapy have limited antitumor effects when used alone. Thus, in the present study, we investigated the antitumor potentials of the combined transfer of the p16 tumor suppressor gene and the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) gene. M...

journal_title：Journal of cancer research and clinical oncology

authors： Wang LH,Ju DW,Sun Y,Tao Q,Qian S,Mi J,Hamada H,Cao X

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies...

journal_title：Journal of cancer research and clinical oncology

authors： Fittkau M,Grothey A,Gerlach R,Schmoll HJ

更新日期：2001-02-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperative...

journal_title：Journal of cancer research and clinical oncology

authors： Gimm O,Sutter T,Dralle H

更新日期：2001-01-01 00:00:00